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"https://dc.uthsc.edu/do/search/advanced/?fq=virtual_ancestor_link:%22https://dc.uthsc.edu/dissertations%22", "https://dc.uthsc.edu/faq.html", "https://dc.uthsc.edu/do/search/advanced/", "/assets/scripts/dc-mobile/dc-mobile-nav.js", "/assets/scripts/yui-init.pack.js", "/assets/scripts/JumpListYUI.pack.js", "/assets/md5images/8e240588cf8cd3a028768d4294acd7d3.png", "https://dc.uthsc.edu/cghs", "https://network.bepress.com/hgg/discipline/733", "https://dc.uthsc.edu/do/discipline_browser/disciplines", "/assets/floatbox/floatbox.css", "/assets/scripts/bepress-init.debug.js", "https://dc.uthsc.edu/dissertations/153", "http://dx.doi.org/10.21007/etd.cghs.2013.0190", "/assets/md5images/7ae5df13ab030c2df97c43673959d834.png", "//cdnjs.cloudflare.com/ajax/libs/yui/3.6.0/yui/yui-min.js", "/ir-style.css", "https://network.bepress.com", "https://dc.uthsc.edu/about.html", "/assets/scripts/article-downloads.pack.js", "../ir-custom.css", "http://uthsc.edu", "https://dc.uthsc.edu/dissertations/171", "#main", "/recent.rss", "https://dc.uthsc.edu", "https://dc.uthsc.edu/accessibility.html", "https://dc.uthsc.edu/dissertations/announcements.html", "/ir-local.css", "/ir-custom.css", "https://dc.uthsc.edu/dissertations/129", "https://www.elsevier.com/legal/privacy-policy", "//ajax.googleapis.com/ajax/libs/jquery/1.10.2/jquery.min.js", "https://www.elsevier.com/legal/elsevier-website-terms-and-conditions", "https://dc.uthsc.edu/do/search/?q=author%3A%22Hao%20Lou%22\u0026start=0\u0026context=7245055", "/ir-print.css", "https://static.addtoany.com/menu/page.js", "https://www.googletagmanager.com/gtag/js?id=G-MH9F3BP3TP", "https://www.elsevier.com/solutions/digital-commons", "../../assets/md5images/fca18b3cff94b6aff95271c0c227e829.jpg", "/assets/footnoteLinks.js", "https://network.bepress.com/hgg/discipline/734" ], "httpBodyMetaTags": { "description": "Pediatric formulations have received great attention from regulatory agencies in the United States and Europe. Since solid dosage forms such as tablets and capsules will not be able to improve pediatric patients’ compliance, customized pediatric formulations are needed. In response, formulators in the pharmaceutical industry have made significant effort into developing various pediatric formulations. However, developing satisfactory pediatric formulations is a process that is guided by case by case basis. The objective of this current study was to apply the scientific pharmaceutical technology concepts into developing modern pediatric formulations. We have shown that the drug delivery design will be affected by the route of administration and by the type of dosage form utilized. We are hopeful that our approach will serve as a tool to assist formulations development. Three drug molecules and an anion were utilized in this work (Chlorpheniramine Maleate, Prednisone, Sulfamerazine, and Iodide ion). Each drug molecule was utilized according to its physicochemical properties along with the pediatric patients’ needs. As a result, several pediatric formulations were developed. Here is the list: taste masked orally disintegrating tablet, taste masked orally disintegrating film, taste masked mini-tablet, reconstituted nanocrystals and a transdermal microemulsion. We are hopeful that these dosage forms will serve as good examples for specialized pediatric formulations and will attract pharmaceutical industry to adapt some these delivery systems into their development strategy.", "og:description": "Pediatric formulations have received great attention from regulatory agencies in the United States and Europe. Since solid dosage forms such as tablets and capsules will not be able to improve pediatric patients’ compliance, customized pediatric formulations are needed. In response, formulators in the pharmaceutical industry have made significant effort into developing various pediatric formulations. However, developing satisfactory pediatric formulations is a process that is guided by case by case basis. The objective of this current study was to apply the scientific pharmaceutical technology concepts into developing modern pediatric formulations. We have shown that the drug delivery design will be affected by the route of administration and by the type of dosage form utilized. We are hopeful that our approach will serve as a tool to assist formulations development. Three drug molecules and an anion were utilized in this work (Chlorpheniramine Maleate, Prednisone, Sulfamerazine, and Iodide ion). Each drug molecule was utilized according to its physicochemical properties along with the pediatric patients’ needs. As a result, several pediatric formulations were developed. Here is the list: taste masked orally disintegrating tablet, taste masked orally disintegrating film, taste masked mini-tablet, reconstituted nanocrystals and a transdermal microemulsion. We are hopeful that these dosage forms will serve as good examples for specialized pediatric formulations and will attract pharmaceutical industry to adapt some these delivery systems into their development strategy.", "twitter:description": "Pediatric formulations have received great attention from regulatory agencies in the United States and Europe. Since solid dosage forms such as tablets and capsules will not be able to improve pediatric patients’ compliance, customized pediatric formulations are needed. In response, formulators in the pharmaceutical industry have made significant effort into developing various pediatric formulations. However, developing satisfactory pediatric formulations is a process that is guided by case by case basis. The objective of this current study was to apply the scientific pharmaceutical technology concepts into developing modern pediatric formulations. We have shown that the drug delivery design will be affected by the route of administration and by the type of dosage form utilized. We are hopeful that our approach will serve as a tool to assist formulations development. Three drug molecules and an anion were utilized in this work (Chlorpheniramine Maleate, Prednisone, Sulfamerazine, and Iodide ion). Each drug molecule was utilized according to its physicochemical properties along with the pediatric patients’ needs. As a result, several pediatric formulations were developed. Here is the list: taste masked orally disintegrating tablet, taste masked orally disintegrating film, taste masked mini-tablet, reconstituted nanocrystals and a transdermal microemulsion. We are hopeful that these dosage forms will serve as good examples for specialized pediatric formulations and will attract pharmaceutical industry to adapt some these delivery systems into their development strategy." }, "httpBodyByteSize": 33445, "httpBodyPageTitle": "\"A Series of Pharmaceutical Technology Concepts Applied to Pediatric Fo\" by Hao Lou" }, "/dissertations/699/": { "date": "2026-02-06T19:50:21Z", "httpProtocol": "h2, tls/1.3", "httpStatus": 200, "ipAddress": "50.18.241.247", "ipASN": "Amazon.com, Inc.", "ipCountry": "United States", "httpHeaderHash": "QD3SEBP7AEVR5X62OPHEMNK5SIDBJN44", "httpHeaderTechnologies": [ "HSTS", "Nginx" ], "httpHeaderUrls": [], "httpHeaderByteSize": 474, "httpBodyHash": "Z37SR4F6E3M4GMYBCFJXC3FLIB2GFWJ4", "httpBodyTechnologies": [ "Responsive Nav", "Google Analytics", "Bootstrap:20160726", "AddToAny", "Cloudflare", "jQuery:1.10.2", "Google Hosted Libraries", "YUI", "cdnjs" ], "httpBodyUrls": [ "https://www.elsevier.com/solutions/digital-commons", "https://dc.uthsc.edu/cgi/viewcontent.cgi?article=1699\u0026context=dissertations", "https://dc.uthsc.edu/cghs", "http://dx.doi.org/10.21007/etd.cghs.2024.0679", "../ir-custom.css", "/assets/floatbox/floatbox.css", "https://dc.uthsc.edu/communities.html", "//ajax.googleapis.com/ajax/libs/jquery/1.10.2/jquery.min.js", "https://www.elsevier.com/legal/elsevier-website-terms-and-conditions", "../ir-local.css", "/assets/jsUtilities.js", "https://dc.uthsc.edu/authors.html", "/assets/scripts/bpbootstrap-20160726.pack.js", "https://dc.uthsc.edu/cgi/viewcontent.cgi?filename=0\u0026article=1699\u0026context=dissertations\u0026type=additional", "//cdn.plu.mx/widget-popup.js", "/assets/scripts/article-downloads.pack.js", "0000-0002-1660-9916", "https://dc.uthsc.edu", "/assets/scripts/JumpListYUI.pack.js", "https://dc.uthsc.edu/do/discipline_browser/disciplines", "https://assets.adobedtm.com/4a848ae9611a/d0e96722185b/launch-d525bb0064d8.min.js", "/ir-local.css", "/ir-custom.css", "https://network.bepress.com", "/assets/floatbox/floatbox.js", "/assets/scripts/yui-init.pack.js", "https://network.bepress.com/hgg/discipline/669", "/ir-style.css", "https://dc.uthsc.edu/dissertations/686", "https://dc.uthsc.edu/dissertations/699", "https://dc.uthsc.edu/do/search/advanced/", "/favicon.ico", "https://dc.uthsc.edu/dissertations/698", "https://dc.uthsc.edu/accessibility.html", "/cgi/myaccount.cgi?context=dissertations", "https://static.addtoany.com/menu/page.js", "/assets/scripts/dc-mobile/dc-mobile-nav.js", "https://www.elsevier.com/legal/privacy-policy", "#main", "/assets/nr_browser_production.js", "https://dc.uthsc.edu/etd_programs", "/assets/scripts/bepress-init.debug.js", "/recent.rss", "/assets/md5images/7ae5df13ab030c2df97c43673959d834.png", "https://dc.uthsc.edu/faq.html", "https://www.googletagmanager.com/gtag/js?id=G-MH9F3BP3TP", "//cdnjs.cloudflare.com/ajax/libs/yui/3.6.0/yui/yui-min.js", "../../assets/md5images/fca18b3cff94b6aff95271c0c227e829.jpg", "https://dc.uthsc.edu/cgi/myaccount.cgi?context=dissertations", "/assets/footnoteLinks.js", "https://network.bepress.com/hgg/discipline/924", "/assets/md5images/f747ac8286efaa7a48c6f87e45ee3382.png", "https://plu.mx/plum/a/?repo_url=https://dc.uthsc.edu/dissertations/699", "https://dc.uthsc.edu/do/search/?q=author%3A%22Menglin%20Jiang%22\u0026start=0\u0026context=7245055", "https://dc.uthsc.edu/dissertations/announcements.html", "/assets/md5images/8e240588cf8cd3a028768d4294acd7d3.png", "https://dc.uthsc.edu/dissertations", "/ir-print.css", "http://uthsc.edu", "https://dc.uthsc.edu/about.html", "https://dc.uthsc.edu/do/search/advanced/?fq=virtual_ancestor_link:%22https://dc.uthsc.edu/dissertations%22", "/assets/scripts/dc-mobile/dc-responsive-nav.js" ], "httpBodyMetaTags": { "description": "Regulatory T (Treg) cells play a pivotal role in maintaining immune homeostasis and preventing autoimmunity. Like most T cells, Treg development occurs primarily in the thymus, where T-cell precursors undergo a series of developmental stages, including double-negative (DN), double-positive (DP), and single-positive (SP) stages, leading to the formation of distinct mature T cells. To ensure a diverse and self-tolerant T-cell repertoire capable of effectively responding to a wide range of pathogens while preventing autoimmunity, the differentiation process of thymocytes is closely supervised by sequential programs, including the rearrangement of T-cell receptor (TCR) gene segments, β-selection of cells expressing a functional TCRβ chain, positive selection of cells followed by CD4/CD8 lineage specificity, and negative selection or clonal deletion to eliminate autoreactive T cells. The induction of the Treg population is triggered when autoreactive cells escape from negative selection. Despite significant progress in our understanding of thymic T-cell differentiation, investigating how thymic Treg cells differentiate in their native settings remains a key conceptual and technical challenge. One major issue is that previous investigations have been limited by technological constraints. First, studies often rely on predefined markers, which can introduce bias in defining developmental stages. Second, techniques such as adoptive T-cell transfer and in vitro culture of TCR transgenic can induce stress on the cells, emphasizing the necessity of studying T-cell development under native physiological conditions. Third, the thymic T-cell pool is a mix of cells derived at any developmental stages as well as mature T cells recirculating back into thymus. Such heterogeneity complexes the assessment focusing on differentiating thymocytes. To address these challenges, we developed a Rag1CreER timestamping mouse model. This model is based on the CreER-loxp system and enables tracing thymocytes at their earlier stage by tamoxifen-induced Cre recombinase. When combined with Rosa reporter strains, this genetic tool enables inducible labeling of early T cells at the T-cell receptor (TCR) rearrangement stage at any time, allowing temporal tracking of their developmental trajectories. By integrating timestamp tracing with single-cell technology, our deconvolution of thymic cells delineated the dynamic processes of developmental stages, and transcriptome profiles during thymic T-cell differentiation. This method provides a comprehensive and high-resolution view of thymic T-cell differentiation under natural conditions. We identified intermediate CD4 SP thymocytes that precede Treg induction, these cells are featured with Treg-associated gene signatures such as high levels of Tnfrsf9, Tnfrsf4, Ikzf2, Ikzf4 and Il2ra. These cells are induced by TCR signaling through various", "og:description": "Regulatory T (Treg) cells play a pivotal role in maintaining immune homeostasis and preventing autoimmunity. Like most T cells, Treg development occurs primarily in the thymus, where T-cell precursors undergo a series of developmental stages, including double-negative (DN), double-positive (DP), and single-positive (SP) stages, leading to the formation of distinct mature T cells. To ensure a diverse and self-tolerant T-cell repertoire capable of effectively responding to a wide range of pathogens while preventing autoimmunity, the differentiation process of thymocytes is closely supervised by sequential programs, including the rearrangement of T-cell receptor (TCR) gene segments, β-selection of cells expressing a functional TCRβ chain, positive selection of cells followed by CD4/CD8 lineage specificity, and negative selection or clonal deletion to eliminate autoreactive T cells. The induction of the Treg population is triggered when autoreactive cells escape from negative selection. Despite significant progress in our understanding of thymic T-cell differentiation, investigating how thymic Treg cells differentiate in their native settings remains a key conceptual and technical challenge. One major issue is that previous investigations have been limited by technological constraints. First, studies often rely on predefined markers, which can introduce bias in defining developmental stages. Second, techniques such as adoptive T-cell transfer and in vitro culture of TCR transgenic can induce stress on the cells, emphasizing the necessity of studying T-cell development under native physiological conditions. Third, the thymic T-cell pool is a mix of cells derived at any developmental stages as well as mature T cells recirculating back into thymus. Such heterogeneity complexes the assessment focusing on differentiating thymocytes. To address these challenges, we developed a Rag1CreER timestamping mouse model. This model is based on the CreER-loxp system and enables tracing thymocytes at their earlier stage by tamoxifen-induced Cre recombinase. When combined with Rosa reporter strains, this genetic tool enables inducible labeling of early T cells at the T-cell receptor (TCR) rearrangement stage at any time, allowing temporal tracking of their developmental trajectories. By integrating timestamp tracing with single-cell technology, our deconvolution of thymic cells delineated the dynamic processes of developmental stages, and transcriptome profiles during thymic T-cell differentiation. This method provides a comprehensive and high-resolution view of thymic T-cell differentiation under natural conditions. We identified intermediate CD4 SP thymocytes that precede Treg induction, these cells are featured with Treg-associated gene signatures such as high levels of Tnfrsf9, Tnfrsf4, Ikzf2, Ikzf4 and Il2ra. These cells are induced by TCR signaling through various", "twitter:description": "Regulatory T (Treg) cells play a pivotal role in maintaining immune homeostasis and preventing autoimmunity. Like most T cells, Treg development occurs primarily in the thymus, where T-cell precursors undergo a series of developmental stages, including double-negative (DN), double-positive (DP), and single-positive (SP) stages, leading to the formation of distinct mature T cells. To ensure a diverse and self-tolerant T-cell repertoire capable of effectively responding to a wide range of pathogens while preventing autoimmunity, the differentiation process of thymocytes is closely supervised by sequential programs, including the rearrangement of T-cell receptor (TCR) gene segments, β-selection of cells expressing a functional TCRβ chain, positive selection of cells followed by CD4/CD8 lineage specificity, and negative selection or clonal deletion to eliminate autoreactive T cells. The induction of the Treg population is triggered when autoreactive cells escape from negative selection. Despite significant progress in our understanding of thymic T-cell differentiation, investigating how thymic Treg cells differentiate in their native settings remains a key conceptual and technical challenge. One major issue is that previous investigations have been limited by technological constraints. First, studies often rely on predefined markers, which can introduce bias in defining developmental stages. Second, techniques such as adoptive T-cell transfer and in vitro culture of TCR transgenic can induce stress on the cells, emphasizing the necessity of studying T-cell development under native physiological conditions. Third, the thymic T-cell pool is a mix of cells derived at any developmental stages as well as mature T cells recirculating back into thymus. Such heterogeneity complexes the assessment focusing on differentiating thymocytes. To address these challenges, we developed a Rag1CreER timestamping mouse model. This model is based on the CreER-loxp system and enables tracing thymocytes at their earlier stage by tamoxifen-induced Cre recombinase. When combined with Rosa reporter strains, this genetic tool enables inducible labeling of early T cells at the T-cell receptor (TCR) rearrangement stage at any time, allowing temporal tracking of their developmental trajectories. By integrating timestamp tracing with single-cell technology, our deconvolution of thymic cells delineated the dynamic processes of developmental stages, and transcriptome profiles during thymic T-cell differentiation. This method provides a comprehensive and high-resolution view of thymic T-cell differentiation under natural conditions. We identified intermediate CD4 SP thymocytes that precede Treg induction, these cells are featured with Treg-associated gene signatures such as high levels of Tnfrsf9, Tnfrsf4, Ikzf2, Ikzf4 and Il2ra. These cells are induced by TCR signaling through various" }, "httpBodyByteSize": 42212, "httpBodyPageTitle": "\"On Thymic Regulatory T-Cell Ontogeny\" by Menglin Jiang" }, "/dnp/125/": { "date": "2026-02-06T19:03:10Z", "httpProtocol": "h2, tls/1.3", "httpStatus": 200, "ipAddress": "13.57.92.51", "ipASN": "Amazon.com, Inc.", "ipCountry": "United States", "httpHeaderHash": "T5ZHPAPF4XH4A5AT3TXWBYU4BPGJRTMF", "httpHeaderTechnologies": [ "Nginx", "HSTS" ], "httpHeaderUrls": [], "httpHeaderByteSize": 474, "httpBodyHash": "XIIS4IERLPYEUERLNZVVFLZOE7EBZLGA", "httpBodyTechnologies": [ "AddToAny", "Cloudflare", "jQuery:1.10.2", "Google Analytics", "Bootstrap:20160726", "cdnjs", "Responsive Nav", "Google Hosted Libraries", "YUI" ], "httpBodyUrls": [ "/assets/scripts/dc-mobile/dc-responsive-nav.js", "https://dc.uthsc.edu/dnp", "//cdn.plu.mx/widget-popup.js", "/assets/floatbox/floatbox.css", "/assets/scripts/article-downloads.pack.js", "https://network.bepress.com/api/follow/subscribe?user=YTM1YzJmZmVhZjU1NjQwZg%3D%3D\u0026institution=OGEzMDllYTJkY2ZkMzIwZg%3D%3D\u0026format=html", "/ir-print.css", "https://dc.uthsc.edu/cgi/viewcontent.cgi?article=1127\u0026context=dnp", "#main", "../ir-local.css", "https://dc.uthsc.edu/do/search/advanced/", "https://dc.uthsc.edu/do/search/?q=%28author%3A%22Tia%20Glover%20BSN%2C%20RN%22%20AND%20-bp_author_id%3A%5B%2A%20TO%20%2A%5D%29%20OR%20bp_author_id%3A%28%224fd8ea13-60fd-414a-9004-dc90708c3293%22%29\u0026start=0\u0026context=7245055", "/ir-style.css", "/assets/jsUtilities.js", "https://dc.uthsc.edu/about.html", "https://dc.uthsc.edu/communities.html", "https://static.addtoany.com/menu/page.js", "https://dc.uthsc.edu/dnp/announcements.html", "https://network.bepress.com/hgg/discipline/1430", "https://www.elsevier.com/solutions/digital-commons", "https://dc.uthsc.edu/dnp/guidelines.html", "https://network.bepress.com/api/follow/subscribe?user=YmQ4YmM2MzYyYzBhZGI4OQ%3D%3D\u0026institution=OGEzMDllYTJkY2ZkMzIwZg%3D%3D\u0026format=html", "https://dc.uthsc.edu/do/search/?q=%28author%3A%22Leslie%20Asplund%20BSN%2C%20RN%22%20AND%20-bp_author_id%3A%5B%2A%20TO%20%2A%5D%29%20OR%20bp_author_id%3A%28%22f9a79ea4-4e58-4f34-a317-2fd8fd768df4%22%29\u0026start=0\u0026context=7245055", "https://dc.uthsc.edu/faq.html", "/assets/scripts/bepress-init.debug.js", "/assets/scripts/bpbootstrap-20160726.pack.js", "https://network.bepress.com/hgg/discipline/727", "../../assets/md5images/ec3002bd1fa686e801c52b2244c0cb25.jpg", "//ajax.googleapis.com/ajax/libs/jquery/1.10.2/jquery.min.js", "https://www.elsevier.com/legal/elsevier-website-terms-and-conditions", "https://dc.uthsc.edu", "https://dc.uthsc.edu/con", "https://www.googletagmanager.com/gtag/js?id=G-MH9F3BP3TP", "/assets/scripts/yui-init.pack.js", "https://network.bepress.com", "/assets/scripts/dc-mobile/dc-mobile-nav.js", "/favicon.ico", "../ir-custom.css", "https://dc.uthsc.edu/dnp/122", "https://www.elsevier.com/legal/privacy-policy", "https://network.bepress.com/api/follow/subscribe?user=ZGM4MGRiZWY1NDY1NjZkOQ%3D%3D\u0026institution=OGEzMDllYTJkY2ZkMzIwZg%3D%3D\u0026format=html", "/recent.rss", "/assets/footnoteLinks.js", "http://dx.doi.org/10.21007/con.dnp.2025.0126", "/assets/md5images/f747ac8286efaa7a48c6f87e45ee3382.png", "https://dc.uthsc.edu/do/discipline_browser/disciplines", "https://dc.uthsc.edu/do/search/advanced/?fq=virtual_ancestor_link:%22https://dc.uthsc.edu/dnp%22", "https://dc.uthsc.edu/authors.html", "http://uthsc.edu", "https://network.bepress.com/hgg/discipline/1363", "https://dc.uthsc.edu/cgi/myaccount.cgi?context=dnp", "https://assets.adobedtm.com/4a848ae9611a/d0e96722185b/launch-d525bb0064d8.min.js", "https://dc.uthsc.edu/do/search/?q=%28author%3A%22Tracy%20McClinton%20DNP%2C%20APRN%2C%20AGACNP-BC%2C%20HGET-C%2C%20EBP-C%22%20AND%20-bp_author_id%3A%5B%2A%20TO%20%2A%5D%29%20OR%20bp_author_id%3A%28%226019839b-09a3-4025-9bf6-904088abfddd%22%29\u0026start=0\u0026context=7245055", "https://dc.uthsc.edu/dnp/119", "/cgi/myaccount.cgi?context=dnp", "/assets/scripts/JumpListYUI.pack.js", "/ir-local.css", "https://dc.uthsc.edu/cgi/ir_submit.cgi?context=dnp", "/assets/nr_browser_production.js", "https://doi.org/10.21007/con.dnp.2025.0126", "/assets/md5images/7ae5df13ab030c2df97c43673959d834.png", "//cdnjs.cloudflare.com/ajax/libs/yui/3.6.0/yui/yui-min.js", "https://plu.mx/plum/a/?repo_url=https://dc.uthsc.edu/dnp/125", "https://network.bepress.com/hgg/discipline/719", "/assets/md5images/8e240588cf8cd3a028768d4294acd7d3.png", "/ir-custom.css", "/assets/floatbox/floatbox.js", "https://dc.uthsc.edu/dnp/125", "https://dc.uthsc.edu/accessibility.html" ], "httpBodyMetaTags": { "description": "Purpose/Background\nPulmonary embolism (PE) is a critical cardiovascular emergency associated with high morbidity and mortality. Despite its prevalence, traditional PE management often lacks cohesion, leading to suboptimal outcomes. Pulmonary Embolism Response Teams (PERTs) offer a multidisciplinary approach aimed at improving patient outcomes by streamlining diagnosis, facilitating timely interventions, and promoting evidence-based treatment. This scoping review evaluates the evidence supporting PERT efficacy across various clinical and resource-related outcomes with the aim to decrease mortality rates, shorten inpatient length of stay, improve cost efficacy, and minimize adverse events from treatment modalities.\nMethods\nA comprehensive literature search was conducted using PRISMA guidelines across databases, including PubMed, Cochrane Library, and CINAHL. Search terms included “pulmonary embolism,” “PERT,” “clinical protocols,” and “time to intervention.” Inclusion criteria encompassed studies on adult inpatients managed by PERTs, published within the last eight years. Of 38 articles initially identified, 13 met inclusion criteria. Data were charted and synthesized to evaluate PERT outcomes. A levels of evidence table was created to classify the strength of the studies, and an outcomes synthesis table was used to organize and display key findings for analysis.\nResults\nPERT implementation reduced hospital stays by up to two days and ICU stays by 1.5 days. Studies reported a 15% decrease in 30-day mortality rates for patients managed by PERT compared to traditional care pathways. PERT facilitated faster diagnostic and therapeutic 3 interventions, with time to intervention reduced by 30–40% in critically ill patients. Additionally, advanced treatment modalities, such as catheter-directed thrombolysis (CDT) and extracorporeal membrane oxygenation (ECMO), were more frequently utilized. Cost efficacy was achieved through shorter hospitalizations and optimized resource allocation.\nImplications for Nursing Practice\nPERTs improve clinical outcomes and enhance resource efficiency in acute care settings. For advanced practice providers, PERT offers a collaborative framework that supports rapid, evidence-based decision-making and facilitates improved outcomes for patients with pulmonary embolism. The findings underscore the need for widespread adoption of PERT in acute care settings to standardize treatment approaches and enhance patient care. Standardization of PERT protocols and further research on long-term outcomes are recommended to solidify its role in PE management.", "og:description": "Purpose/Background\nPulmonary embolism (PE) is a critical cardiovascular emergency associated with high morbidity and mortality. Despite its prevalence, traditional PE management often lacks cohesion, leading to suboptimal outcomes. Pulmonary Embolism Response Teams (PERTs) offer a multidisciplinary approach aimed at improving patient outcomes by streamlining diagnosis, facilitating timely interventions, and promoting evidence-based treatment. This scoping review evaluates the evidence supporting PERT efficacy across various clinical and resource-related outcomes with the aim to decrease mortality rates, shorten inpatient length of stay, improve cost efficacy, and minimize adverse events from treatment modalities.\nMethods\nA comprehensive literature search was conducted using PRISMA guidelines across databases, including PubMed, Cochrane Library, and CINAHL. Search terms included “pulmonary embolism,” “PERT,” “clinical protocols,” and “time to intervention.” Inclusion criteria encompassed studies on adult inpatients managed by PERTs, published within the last eight years. Of 38 articles initially identified, 13 met inclusion criteria. Data were charted and synthesized to evaluate PERT outcomes. A levels of evidence table was created to classify the strength of the studies, and an outcomes synthesis table was used to organize and display key findings for analysis.\nResults\nPERT implementation reduced hospital stays by up to two days and ICU stays by 1.5 days. Studies reported a 15% decrease in 30-day mortality rates for patients managed by PERT compared to traditional care pathways. PERT facilitated faster diagnostic and therapeutic 3 interventions, with time to intervention reduced by 30–40% in critically ill patients. Additionally, advanced treatment modalities, such as catheter-directed thrombolysis (CDT) and extracorporeal membrane oxygenation (ECMO), were more frequently utilized. Cost efficacy was achieved through shorter hospitalizations and optimized resource allocation.\nImplications for Nursing Practice\nPERTs improve clinical outcomes and enhance resource efficiency in acute care settings. For advanced practice providers, PERT offers a collaborative framework that supports rapid, evidence-based decision-making and facilitates improved outcomes for patients with pulmonary embolism. The findings underscore the need for widespread adoption of PERT in acute care settings to standardize treatment approaches and enhance patient care. Standardization of PERT protocols and further research on long-term outcomes are recommended to solidify its role in PE management.", "twitter:description": "Purpose/Background\nPulmonary embolism (PE) is a critical cardiovascular emergency associated with high morbidity and mortality. Despite its prevalence, traditional PE management often lacks cohesion, leading to suboptimal outcomes. Pulmonary Embolism Response Teams (PERTs) offer a multidisciplinary approach aimed at improving patient outcomes by streamlining diagnosis, facilitating timely interventions, and promoting evidence-based treatment. This scoping review evaluates the evidence supporting PERT efficacy across various clinical and resource-related outcomes with the aim to decrease mortality rates, shorten inpatient length of stay, improve cost efficacy, and minimize adverse events from treatment modalities.\nMethods\nA comprehensive literature search was conducted using PRISMA guidelines across databases, including PubMed, Cochrane Library, and CINAHL. Search terms included “pulmonary embolism,” “PERT,” “clinical protocols,” and “time to intervention.” Inclusion criteria encompassed studies on adult inpatients managed by PERTs, published within the last eight years. Of 38 articles initially identified, 13 met inclusion criteria. Data were charted and synthesized to evaluate PERT outcomes. A levels of evidence table was created to classify the strength of the studies, and an outcomes synthesis table was used to organize and display key findings for analysis.\nResults\nPERT implementation reduced hospital stays by up to two days and ICU stays by 1.5 days. Studies reported a 15% decrease in 30-day mortality rates for patients managed by PERT compared to traditional care pathways. PERT facilitated faster diagnostic and therapeutic 3 interventions, with time to intervention reduced by 30–40% in critically ill patients. Additionally, advanced treatment modalities, such as catheter-directed thrombolysis (CDT) and extracorporeal membrane oxygenation (ECMO), were more frequently utilized. Cost efficacy was achieved through shorter hospitalizations and optimized resource allocation.\nImplications for Nursing Practice\nPERTs improve clinical outcomes and enhance resource efficiency in acute care settings. For advanced practice providers, PERT offers a collaborative framework that supports rapid, evidence-based decision-making and facilitates improved outcomes for patients with pulmonary embolism. The findings underscore the need for widespread adoption of PERT in acute care settings to standardize treatment approaches and enhance patient care. Standardization of PERT protocols and further research on long-term outcomes are recommended to solidify its role in PE management." }, "httpBodyByteSize": 41754, "httpBodyPageTitle": "\"Pulmonary Embolism Response Team in Acute Care Settings: A scoping Rev\" by Tia Glover BSN, RN, Leslie Asplund BSN, RN et al." }, "/residency-programs/emergency-medicine/about-us/training-sites/": { "date": "2026-02-13T12:47:42Z", "httpProtocol": "http/1.1, tls/1.3", "httpStatus": 200, "ipAddress": "128.169.0.41", "ipASN": "The University of Tennessee Health Science Center", "ipCountry": "United States", "httpHeaderHash": "5MH64YAE5FYVBMV6HNIE5PYF4AUQMFNB", "httpHeaderTechnologies": [ "MySQL", "Red Hat", "WordPress", "PHP:8.0.30", "OpenSSL:3.5.1", "Apache HTTP Server:2.4.62" ], "httpHeaderUrls": [], "httpHeaderByteSize": 789, "httpBodyHash": "C52SFR7KHVNR4E2ZZ72YM3LZG423WY2S", "httpBodyTechnologies": [ "Breadcrumb NavXT:7.5.0", "WordPress Block Editor", "Google Hosted Libraries", "MySQL", "cdnjs", 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