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However, high costs and technical barriers have limited adoption in low- and middle-income countries. Even in high-income nations, many individuals with epilepsy face delays in undergoing MRI. Recent advancements in ultra-low-field (ULF) MRI technology, particularly the development of portable scanners, offer a promising solution to the limited accessibility of MRI. In this study, we present and evaluate the imaging capability of ULF MRI in detecting structural abnormalities typically associated with epilepsy and compare it to high-field MRI at 3 T.Data collection was conducted within 3 consecutive weeks at the University Hospital Bonn. Inclusion criteria were a minimum age of 18 years, diagnosed epilepsy, and clinical high-field MRI with abnormalities. We used a .064 T Swoop portable MR Imaging System. Both high-field MRI and ULF MRI scans were evaluated independently by two experienced neuroradiologists as part of their clinical routine, comparing pathology detection and diagnosis completeness.Twenty-three individuals with epilepsy were recruited. One subject presented with a dual pathology. Across the entire cohort, in 17 of 24 (71%) pathologies, an anomaly colocalizing with the actual lesion was observed on ULF MRI. For 11 of 24 (46%) pathologies, the full diagnosis could be made based on ULF MRI. Tumors and posttraumatic lesions could be diagnosed best on ULF MRI, whereas cortical dysplasia and other focal pathologies were the least well diagnosed.This single-center series of individuals with epilepsy demonstrates the feasibility and utility of ULF MRI for the field of epileptology. Its integration into epilepsy care offers transformative potential, particularly in resource-limited settings. Further research is needed to position ULF MRI within imaging modalities in the diagnosis of epilepsy.\nBauer, Tobias; Olbrich, Simon; Groteklaes, Anne; Lehnen, Nils Christian; Zidan, Mousa; Lange, Annalena; Bisten, Justus; Walger, Lennart; Faber, Jennifer; Bruchhausen, Walter; Vollmuth, Philipp; Herrlinger, Ulrich; Radbruch, Alexander; Surges, Rainer; Sabir, Hemmen; Rüber, Theodor" }, "httpBodyByteSize": 15245, "httpBodyPageTitle": "Proof of concept: Portable ultra-low-field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies. - DZNEPUB" }, "/record/282575/export/hr?ln=en": { "date": "2026-02-06T23:29:47Z", "httpProtocol": "http/1.1, tls/1.2", "httpStatus": 200, "ipAddress": "193.175.154.48", "ipASN": "Verein zur Foerderung eines Deutschen Forschungsnetzes e.V.", "ipCountry": "Germany", "httpHeaderHash": "XR66GACLJGOWCGOJXVCJ56UMK43CEXCS", "httpHeaderTechnologies": [ "Invenio", "Apache HTTP Server" ], "httpHeaderUrls": [], "httpHeaderByteSize": 748, "httpBodyHash": "YWE76MMGNCZC7CK4WV3BZ5WZGSGWWMOG", "httpBodyTechnologies": [ "jQuery Migrate", "jQuery", "DataTables", "Invenio:1.1.7" ], "httpBodyUrls": [ "https://pub.dzne.de/youraccount/login?ln=en\u0026referer=https%3A//pub.dzne.de/record/282575/export/hr%3Fln%3Den", "https://pub.dzne.de?ln=en", "https://pub.dzne.de/rss?ln=en", "https://pub.dzne.de/help/?ln=en", "https://pub.dzne.de/opensearchdescription", "https://pub.dzne.de/js/jquery-latest.min.js", "https://pub.dzne.de/youralerts/display?ln=en", "https://pub.dzne.de/img/user-icon-1-20x20.gif", "https://pub.dzne.de/record/282575", "http://join2.de", "https://www.dzne.de/impressum", "https://pub.dzne.de/submit?ln=en", "https://pub.dzne.de/youralerts/list?ln=en", "https://pub.dzne.de/js/cookiebanner.min.js", "https://pub.dzne.de/youraccount/display?ln=en", "https://pub.dzne.de/js/jquery/join2LookAndFeel.js", "mailto:j2-admin@dzne.de", "https://pub.dzne.de/unapi", "https://pub.dzne.de/collection/VDB?ln=en", "https://pub.dzne.de/js/jquery-migrate.js", "https://pub.dzne.de/yourbaskets/display?ln=en", "https://pub.dzne.de/js/jquery/jquery.dataTables.min.js", "/img/invenio_dzne.css", "https://pub.dzne.de/?ln=en", "http://invenio-software.org/", "/img/jquery.dataTables.min.css", "https://www.dzne.de/datenschutz" ], "httpBodyMetaTags": { "description": "Iron deposition in the brain has been associated with epilepsy, but its anatomical distribution and its temporal association to seizures remain unclear. Here, we investigate brain iron in individuals with focal epilepsy using interictal and postictal quantitative susceptibility mapping (QSM) at 7 T MRI and explore its functional relevance.80 consecutive participants with focal epilepsy undergoing presurgical evaluation and 50 healthy controls were included. 8/80 participants with focal epilepsy had interictal and postictal scans. High-resolution T1- and susceptibility-weighted images were acquired and processed using custom pipelines for QSM. Seizure onset zones were determined by expert consensus, and neuropsychological assessments included memory and mood. Parcel-wise analyses examined group differences and correlations with cognitive scores, controlling for age and sex.Participants with focal epilepsy showed significantly higher interictal susceptibility, which colocalised with the presumed seizure onset zone. Impaired memory performance and more severe depressive symptoms were correlated with higher interictal susceptibility. Postictal susceptibility was significantly higher than interictal susceptibility and associated to the number of preceding seizures.QSM reflects both ictal iron extravasation and interictal iron accumulation. If further validated, it may help to non-invasively delineate the epileptogenic zone and become a long-term biomarker for seizure-burden.N.R.H. and T.Bauer were supported by the BONFOR research commission of the Medical Faculty of the University of Bonn. T.Bauer was funded by the Deutsche Forschungsgemeinschaft. T.Bauer., L.W., A.L. and T.R. are funded by the German Ministry for Research, Technology and Space.\nHeld, Nina Rebecca; Bauer, Tobias; Stirnberg, Rüdiger; Recke, Theda von der; Lehnen, Nils Christian; Baumgartner, Tobias; Witt, Juri-Alexander; Rácz, Attila; Pukropski, Jan; Walger, Lennart; von Wrede, Randi; Badr, Mostafa; Wolf, David; Kersting, Lennart Nils; Lange, Annalena; Bisten, Justus; Schmidt, Markus; Pracht, Eberhard; Löwen, Daniel; Faber, Jennifer; Helmstaedter, Christoph; Reuter, Martin; Friedman, Alon; Radbruch, Alexander; Surges, Rainer; Stöcker, Tony; Rüber, Theodor" }, "httpBodyByteSize": 14231, "httpBodyPageTitle": "Quantitative susceptibility mapping at 7T as a biomarker of post- and interictal extravascular iron in patients with focal epilepsy. - DZNEPUB" }, "/record/282933/export/hx?ln=en": { "date": "2026-02-13T22:42:39Z", "httpProtocol": "http/1.1, tls/1.2", "httpStatus": 200, "ipAddress": "193.175.154.48", "ipASN": "Verein zur Foerderung eines Deutschen Forschungsnetzes e.V.", "ipCountry": "Germany", "httpHeaderHash": "XLA5ODRCS53GPPXBTBFRXX473OBUWN65", "httpHeaderTechnologies": [ "Invenio", "Apache HTTP Server" ], "httpHeaderUrls": [], "httpHeaderByteSize": 748, "httpBodyHash": "PDOS4OLTYB2RVXLV3VH5UWHKVQPKFUVZ", "httpBodyTechnologies": [ "jQuery", "DataTables", "Invenio:1.1.7", "jQuery Migrate" ], "httpBodyUrls": [ "https://pub.dzne.de/?ln=en", "http://invenio-software.org/", "https://pub.dzne.de/rss?ln=en", "https://pub.dzne.de/help/?ln=en", "https://www.dzne.de/datenschutz", "https://pub.dzne.de/submit?ln=en", "https://pub.dzne.de/youraccount/display?ln=en", "http://join2.de", "https://pub.dzne.de/unapi", "/img/jquery.dataTables.min.css", "https://pub.dzne.de/opensearchdescription", "https://pub.dzne.de/youralerts/display?ln=en", "https://pub.dzne.de/yourbaskets/display?ln=en", "https://pub.dzne.de/youraccount/login?ln=en\u0026referer=https%3A//pub.dzne.de/record/282933/export/hx%3Fln%3Den", "mailto:j2-admin@dzne.de", "https://pub.dzne.de?ln=en", "https://www.dzne.de/impressum", "https://pub.dzne.de/collection/VDB?ln=en", "https://pub.dzne.de/js/cookiebanner.min.js", "https://pub.dzne.de/js/jquery/join2LookAndFeel.js", "https://pub.dzne.de/js/jquery/jquery.dataTables.min.js", "https://pub.dzne.de/record/282933", "https://pub.dzne.de/js/jquery-migrate.js", "https://pub.dzne.de/youralerts/list?ln=en", "https://pub.dzne.de/js/jquery-latest.min.js", "https://pub.dzne.de/img/user-icon-1-20x20.gif", "/img/invenio_dzne.css" ], "httpBodyMetaTags": { "description": "The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical trials with BACE1 inhibitors were stopped because of an adverse event, a mild cognitive worsening. The underlying mechanism is not yet known but may result from co-inhibition of the BACE1-homolog BACE2. While a cerebrospinal fluid (CSF) biomarker for measuring BACE2 activity is not yet established, VCAM-1 has been suggested as such a biomarker, but has not yet been tested upon prolonged dosing in vivo. Using CSF pharmacoproteomics and a subchronic dosing paradigm in non-human primates, we demonstrate that compound 89, a BACE inhibitor not yet tested in humans, and the clinically tested drug elenbecestat inhibit BACE1 in vivo, with little or no effect on BACE2, as seen with a reduction of substrates of BACE1, but not of the BACE2 substrate VCAM-1. As a control, verubecestat, which inhibits both BACE2 and BACE1, reduced CSF abundance of BACE1 substrates as well as of VCAM-1. This study demonstrates the suitability of VCAM-1 as a pharmacodynamic biomarker for measuring BACE2 target engagement in CSF.\nNalbach, Karsten; Lichtenthaler, Stefan" }, "httpBodyByteSize": 10726, "httpBodyPageTitle": "Dataset: Elenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates (Project PXD067461) - DZNEPUB" }, "/users/sign_in": { "date": "2026-02-13T04:55:47Z", "httpProtocol": "http/1.1, tls/1.2", "httpStatus": 200, "ipAddress": "193.175.154.48", "ipASN": "Verein zur Foerderung eines Deutschen Forschungsnetzes e.V.", "ipCountry": "Germany", "httpHeaderHash": "BPJMYMQWDFYEJSOKKH3YUXKUTKCXMSTF", "httpHeaderTechnologies": [ "Ruby on Rails", "HSTS", "Nginx", "GitLab", "Vue.js" ], "httpHeaderUrls": [], "httpHeaderByteSize": 1150, "httpBodyHash": "K6U4JUN3NTEPO6OFG2VQHRWLVPNP5OIU", "httpBodyTechnologies": [ "Ruby", "Ruby on Rails" ], "httpBodyUrls": [ "https://about.gitlab.com", "/assets/webpack/runtime.97a65ee1.bundle.js", 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